2009年，山东体育大学,生物技术专业，学士学位；
2015年，中国科学院生物物理研究所,细胞生物学专业，博士学位；
2016-2021年，美国北卡罗来纳大学教堂山分校，博士后；
2021-2022年，美国北卡罗来纳大学教堂山分校，研究助理教授；
2021年，国家高层次青年人才;
2022年，beat365正版唯一官网南强青年拔尖A类人才；
2022年，beat365正版唯一官网，教授
B.S. Shandong University, Biotechnology, 2019;
Ph.D. Institute of Biophysics, Chinese Academy of Science, Cell biology, 2015;
Postdoctoral Fellow, University of North Carolina at Chapel hill, 2016-2021;
Research Assistant Professor, University of North Carolina at Chapel hill, 2021-2022;
Professor, School of Life Sciences, Xiamen University, 2022

肠道微生物菌群是寄居在肠道内的数以亿计的微生物总合，包括细菌、真菌、病毒等。肠道微生物菌群具有庞大的基因组组成，使其逐步形成一个多样化的生态系统。肠道微生物与其所产生的大量的多样的代谢产物可以影响机体许多器官的功能，并且帮助维持机体免疫系统的稳态。肠道微生物菌群的调节失衡与多种疾病的发生发展密切相关。本课题组致力于研究肠道微生物菌群在不同疾病模型(包括辐射损伤、肠炎、病毒感染、肿瘤等)中的功能，并尝试研发与肠道微生物和代谢产物相关的疾病诊断和治疗方法。
The gastrointestinal tract harbors a highly complex microbial community, including bacteria, fungus, virus, etc., which is referred to as intestinal microbiota. The entire genome sequence of a microbial community is referred to as the microbiome. With increasing evidence suggesting that the imbalance of gut microbiota plays a significant role in the pathogenesis of multiple diseases, interactions between host immune system and gut microbiota are now attracting emerging interest. Our lab investigates the function of gut microbiota in multiple diseases, such as radiation-induced damage, colitis, viral infection and cancer, etc.. Meanwhile, we will work on developing new diagnostic methods and treatments based on microbiota and related metabolites.

代表性论文(^# co-first author, ^* Corresponding author):

1. Ravichandra Vemuri, Alistaire Ruggiero, Jordyn M Whitfield, Greg O Dugan, J Mark Cline, Masha R Block, Hao Guo, Kylie Kavanagh. Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates. Am J Physiol Heart Circ Physiol. 2022 Mar 1;322(3):H474-H485.
2. Hao Guo, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W Tam, W. June Brickey, Liang Chen, Nathan D. Montgomery, Xin Li, Lauren M. Bohannon, Anthony D. Sung, Nelson J. Chao, Jonathan U. Peled, Antonio L.C. Gomes, Marcel R.M. van den Brink, Matthew J. French, Andrew N. Macintyre, Gregory D. Sempowski, Xianming Tan, R. Balfour Sartor, Kun Lu and Jenny P.Y. Ting. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 30 Oct 2020 :Vol. 370, Issue 6516, eaay9097.
3. Wei-Chun Chou^#, Zengli Guo^#, Hao Guo, Liang Chen, Ge Zhang, Ling Xie, Xianming Tan, Sara A. Gibson, Elena Rampanelli, Yan Wang, Stephanie A. Montgomery, W. June Brickey, Meng Deng, Leslie Freeman, Song Zhang, Maureen A Su, Xian Chen, Yisong Y. Wan^*, Jenny P.-Y. Ting^*. AIM2 in regulatory T (Treg) cells restrains autoimmune diseases. Nature. 2021; 591 (7849), 300-305. ^#*Contributed equally.
4. Hao Guo^#, Sara A. Gibson^#, Jenny P.-Y. Ting. Gut Microbiota, NLR Proteins and Intestinal Homeostasis. Journal of Experimental Medicine. 2020 Oct 5;217(10): e20181832. ^#Contributed equally.
5. Agnieszka D. Truax^#, Liang Chen^#, Jason W. Tam, Ning Cheng, Hao Guo, A. Alicia Koblansky, Wei-Chun Chou, Justin E. Wilson, W. June Brickey, Alex Petrucelli, Rongrong Liu, Daniel E. Cooper, Mark J. Koenigsknecht, Vincent B. Young, Mihai G. Netea, Rinke Stienstra, R. Balfour Sartor, Stephanie A. Montgomery, Rosalind A. Coleman, and Jenny P.-Y. Ting. The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host & Microbe. 2018; 24, 364–378. ^#Contributed equally.
6. Cathryn J. Kurkjian^#, Hao Guo^#, Nathan D. Montgomery, Ning Cheng, Hong Yuan, Joseph R. Merrill, Gregory D. Sempowski, W. June Brickey, and Jenny P.-Y. Ting. The Toll–Like Receptor 2 agonist, FSL-1 lipopeptide, therapeutically mitigates acute radiation syndrome. Scientific Reports. 2017; 7: 17355. ^#Contributed equally.
7. Xuyuan Zhang, Pan Yang, Nan Wang, Jialong Zhang, Jingyun Li, Hao Guo, Xiangyun Yin, Zihe Rao, Xiangxi Wang, and Liguo Zhang. The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein Cell. 2017;8(8):590-600. doi:10.1007/s13238-017-0405-7.
8. Xiangyun Yin, Haisheng Yu, Xiaoyang Jin, Jingyun Li, Hao Guo, Quanxing Shi, Zhao Yin, Yong Xu, Xuefei Wang, Rong Liu, Shouli Wang, and Liguo Zhang. Human Blood CD1c+ Dendritic Cells Encompass CD5 high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions. The Journal of Immunology, 2017 Feb 15;198(4):1553-1564. doi: 10.4049/jimmunol.1600193.
9. Hao Guo, Jialong Zhang, Xuyuan Zhang, Yanbing Wang, Haisheng Yu, Xiangyun Yin, Jingyun Li, Peishuang Du, Joel Plumas, Laurence Chaperot, Jianzhu Chen, Lishan Su, Yongjun Liu, and Liguo Zhang. SCARB2/LIMP-2 Regulates Interferon Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7. The Journal of Immunology, 2015; 194(10):4737-49.

荣誉、奖励及参加学术团体的情况:

2020                Joseph S. Pagano Award
2018-2019        Layton family grant for microbiome research
2017-2018        Layton family grant for microbiome research
2013-2014        “Triple-A” Outstanding Student, Chinese Academy of Science
2006-2007        National Base of Life Science and Technology Education Merit Scholarship, Shandong University
2005-2006        Shandong University Merit Scholarship