1986年，第四军医大学基础医学专业，学士学位；
1991年，第四军医大学临床医学专业，硕士学位；
1996年，上海肿瘤研究所生物化学与分子生物学专业，博士学位；
1998-1999年，德国马克斯-普朗克研究所，博士后；
2000-2006年，加利福尼亚大学尔湾分校，博士后/高级研究员
1998-2006年，德国和美国先后任博士后和高级研究员；
2006年至今，beat365正版唯一官网，闽江学者特聘教授/博士生导师。
2012-2021年，beat365正版唯一官网副院长，分子诊断教育部工程研究中心副主任。
B.S. 1986, The Fourth Military Medical University, Basic Medicine;
M.S. 1991, The Fourth Military Medical University, Clinical Medicine;
Ph.D. 1996, Shanghai Cancer Institute, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Max-Planck Institute for Biochemistry, Germany, 1998-1999;
Postdoctoral Fellow/Senior Researcher, University of California Irvine, 2000-2006;
Professor, School of Life Sciences, Xiamen University, 2006-Present;
Deputy Dean, School of Life Sciences, Xiamen University, 2012-2021.

Wnt信号通路在正常组织发育和肿瘤形成过程中发挥重要作用。我们实验室的兴趣在于，研究该信号通路的主要组份与调节因子在正常以及应激条件下，对于肿瘤发生、发展和组织发育、代谢过程的影响；并以此为基础进行肿瘤、遗传性疾病、代谢性疾病分子标志物的筛选，建立分子诊断新方法、新技术，涉及到表观遗传学、干细胞生物学、分子诊断等生物学前沿领域。
The canonical Wnt signaling pathway plays a central role in normal development and tumorigenesis. We are particularly interested in studying the roles of Wnt signaling components and regulators in tissue development, metabolism, and tumorigenesis under the normal and stress conditions. Our research projects touch on the knowledge frontiers of epigenetics and stem cell biology.

代表性论文(^# co-first author, ^* Corresponding author):

1.He, T^# , Wang, S^# ., Li S^# ., Shen, H^# ., Hou, L., Liu, Y., Wei Y., Xie, F., Zhang, Z., Zhao, Z., Mo, C., Guo, H., Huang, Q., Zhang, R^*., Shen, D^*., and Li, BA^*. Suppression of preadipocyte determination by Sox4 limits white adipocyte hyperplasia in obesity. iScience. 2023 Feb 28;26(4):106289. doi: 10.1016/j.isci.2023.106289. eCollection 2023 Apr 21.
2. Lin KF, Guo JG, Guo XJ, Li QH, Li X, Sun Z, Zhao ZH, Weng J, Wu JZ^*, Zhang R^*, Li BA^*. Fast and visual detection of nucleic acid using One-step RPA-CRISPR Detection (ORCD) System. Analytica Chimica Acta. 2023 Apr 1;1248:340938. doi: 10.1016/j.aca.2023.340938. Epub 2023 Feb 3.
3. Huanming Shen, Ting He, Shuai Wang, Lingfeng Hou, Yixin Wei, Yunjia Liu, Chunli Mo, Zehang Zhao, Weixin You, Huiling Guo^*, Boan Li^*. SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex. Theranostics. 2022; 12(18):7699-7716. doi:10.7150/thno.77102
4. Sun Z, Lin KF, Zhao ZH, Wang Y, Hong XX, Guo JG, Ruan QY, Lu LY, Li X, Zhang R^*, Yang CY^*, Li BA^*. An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system. Sci China Chem. 2022 Jan 25:1-11. doi: 10.1007/s11426-021-1169-1. Online ahead of print. PMID: 35126481
5. Zhang R, Geng GJ, Guo JG, Mi YJ, Zhu XL, Li N, Liu HM, Lin JF, Wang JW, Zhao G, Ye GZ, Li BA^*, Luo QC^*, Jiang J^*. An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer. Cell Commun Signal. 2022 Mar 28;20(1):40. doi: 10.1186/s12964-022-00845-z.
6. Zheng ZZ, Li DY, Du KM, Xu X, Wang NJ, Yuan ZY^*, Li BA^*. "HLA-10-SNP": A new qPCR-based system for rapid, effective, and accurate detection of 10 important SNPs in the HLA region. HLA. 2021 Nov;98(5):459-466. doi: 10.1111/tan.14396. Epub 2021 Sep 9.PMID: 34375029
7. Zhang R, Hong JJ, Yang Q, Ong CT, Li BA^*, Liou YC^*. Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells. Oncogene. 2018 Dec 12. doi: 10.1038/s41388-018-0615-3.
8. Xie YY, Mo CL, Cai YH, Wang WJ, Hong XX, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, and Li BA^* . Pygo2 regulates adiposity and glucose homeostasis via β-Catenin-Axin2-GSK3β signaling pathway. Diabetes. 2018 Oct;67(10):1935-1948. doi: 10.2337/db17-1452.
9. Lin LY, Yang L, Zeng Q, Wang L, Chen ML, Zhao ZH, Ye GD, Luo QC, Lv PY, Guo QW, Li BA^*, Cai JC^*, Cai WY^*. Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer. Mol Cancer. 2018 Apr 24;17(1):84. doi: 10.1186/s12943-018-0834-9.
10. Cai W, Chen G, Luo Q, Liu J, Guo X, Zhang T, Ma F, Yuan L, Li BA^*, Cai J^*. PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells. Mol Cancer Ther. 2017 Jun;16(6):1187-1198.
11. Zheng Z, Zhang P, He G, Liao K, Wang Z, Pan J, Du K, Du J, Li BA^*. Simultaneous detection of 45 fusion genes in leukemia by dual-color fluorescence real-time PCR. Int J Lab Hematol. 2017 Apr;39(2):175-184.
12. Cai WY, Lin LY, Hao H, Zhang SM, Ma F, Hong XX, Zhang H, Liu QF, Ye GD, Sun GB, Liu YJ, Li SN, Xie YY, Cai JC, and Li BA^*. YAP-TEAD and HNF4α repress reciprocally to regulate hepatocarcinogenesis. Hepatology. 2017 Apr;65(4):1206-1221.
13. Zhang ZM, Wu JF, Luo QC, Liu QF, Wu QW, Ye GD, She HQ^*, and Li BA^*. Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway. Oncogene, 2016.09.08，35（36）：4787-4797
14. Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, and Li BA^*. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors. Gastroenterology. 2016 Mar;150(3):659-671.
15. Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J, Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM, Li BA^* .Double-Negative Feedback Loop Between Wnt/β-catenin Signaling and HNF4α Regulates Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma. J Cell Sci. 2013 Dec 15;126(Pt 24):5692-5703.
16. Cai WY, Wei TZ, Luo QC, Wu QW, Liu QF, Yang M, Ye GD, Wu JF, Chen YY, Sun GB, Liu YJ, Zhao WX, Zhang ZM, Li BA^*. Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion. J Cell Sci. 2013, Jul 1;126(Pt 13): 2877-2889.
17. Li BA^*. A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma. Acta Pharmacol Sin. 2012 Jan; 33(1):3-4.
18. Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA^*, Wu Q^*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling . GUT. 2012; 61:714-724.
19. Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, Wei T, Zhang L, Yang M, Liu Q, Ye G, Cheng P, Dai X and Li BA^*. Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol. Cell. Biol. 2010 Dec;30(24):5621-35.
20. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, and Li BA^*, Dai X^*, Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009, 185,811-826.
21. Ye Y, Li B^*. 1'S-1'-Acetoxychavicol acetate (ACA) isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 (HIV-1) by blocking Rev transport. Journal of general Virology. 2006; 87: 2047-2053.

荣誉、奖励及参加学术团体的情况: