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王波教授博导

邮  箱:bowang@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2011年,华中科技大学生物技术专业,学士学位;
2016年,田纳西健康医学中心神经生物学专业,博士学位;
2019年,圣裘德儿童研究医院,博士后;
2020年,beat365正版唯一官网,教授。
B.S. 2011, Huazhong University of Science and Technology, Biotechnology;
PhD. 2016, the University of Tennessee Health Science Center, Neuroscience;
Postdoc., St. Jude Children’s Research Hospital, 2017-2019;
Professor, School of Life Sciences, Xiamen University, 2020 to Present.

阐述RNA代谢的细胞和分子机制,以及代谢紊乱如何导致退行性疾病, 比如ALS/FTD/IBM;深入阐释自噬在神经退行性疾病发生过程中所扮演的角色。
To elucidate the cellular and molecular mechanisms of RNA metabolism and how the dysfunction of RNA metabolism contributes to degenerative diseases, such as ALS/FTD/IBM;To uncover the role of autophagy in the pathogenesis of neurodegeneration.

代表性论文(# co-first author, * Corresponding author):

1.Wang, B., Pareek, G., and Kundu, M. # (2024). ULK/Atg1: phasing in and out of autophagy. Trends Biochem Sci, 4(1), https://doi.org/10.1016/j.tibs.2024.03.004
2.Liang, P.*, Wu, Y.*, Zheng, S.*, Zhang, J., Yang, S., Wang, J., Ma, S., Zhang, M., Gu, Z., Liu, Q., Jiang, W., Xing, Q., and Wang, B.# (2024). Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling. J Cell Biol, 223(4): e202209027
3.Liang, P., and Wang, B.# (2024). An autophagy-independent role of ULK1/ULK2 in mechanotransduction and breast cancer cell migration. Autophagy, 1-2
4.Zhang, M.*, Gu, Z.*, Ma, S., Yang, S., Guo, J., Shu, L., Ge, Y., Chen, Z., and Wang, B. # (2024). SRRM2 Phase Separation Drives Assembly of Nuclear Speckle Subcompartments. Cell Reports, 43(3)
5.Liang, P.*, Zhang, J.*, Wu, W.*, Zheng, S.*, Xu, Z., Yang, S., Wang, J., Ma, S., Xiao, L., Hu, T., Jiang, W., Huang, C., Xing, Q., Kundu, M. #, and Wang, B. # (2023). An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration. EMBO reports, 2023, 24(11): e56850
6.Liang, P. *, Zhang, J. *, and Wang, B. # (2023). Emerging Roles of Ubiquitination in Biomolecular Condensates. Cells 12, 2329-2342
7.Li, D., Vogel, P., Li, XJ., Wang, B.# & Kundu, M.# (2021). ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis. Autophagy, 1-10.
8.Wang, B., Stanford, K. & Kundu, M. (2020). ER-to-Golgi trafficking and its implication in neurological diseases. Cells 9, 408-418.
9.Wang, B., Maxwell, B., Joo, J.H., Gwon, Y., Messing, J., Mishra, A., Shaw, T., Ward, A., Quan, H., Sakurada, S.M., et al. (2019). ULK1/2 regulate stress granule disassembly through phosphorylation and activation of VCP. Mol Cell 74, 1-16. (Cover story)
*Highlighted in Williams ER. Turning off cellular stress. Sci Signal 12:eaax9738, 2019.
10.Wang, B., Joo, JH., Mount, R., Teubner, BJW., Krenzer, A., Ward, AL., Ichhaporia, VP., Elizabeth AJ., Khoriaty, R., Peters ST., et al. (2018). The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest 128, 3319–3332.
11.Wang, B., Iyengar, R., Li-Harms, X., Joo, J.H., Wright, C., Lavado, A., Yang, M., Guan, JL., Green, DR., Cao, X., and Kundu, M. (2017). The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy 3, 1-16. (Cover story)
12.Wang, B. & Kundu, M. (2017). Canonical and noncanonical functions of ULK/Atg1. Curr. Opin. Cell Biol. 45, 47-54.
13.Joo, J.H.*, Wang, B.*, Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, T.I., Lindsten, T., et al. (2016). The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell 62, 491-506. *authors contributed equally. (Cover story)
*Highlighted in Zhao YG and Zhang H. The Incredible ULKs: Autophagy and Beyond. Mol Cell 63:475-476, 2016.
*Highlighted in Strzyz P. The second job of ULKs. Nat Rev Mol Cell Biol 17:396–397, 2016.
14.Kim, N.C., Tresse, E., Kolaitis, R.M., Molliex, A., Thomas, R.E., Alami, N.H., Wang, B., Joshi, A., Smith, R.B., Ritson, G.P., et al. (2013). VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 78, 65-80.
15.Xiao, L., Wang, B., Yang, G., and Gauthier, G. (2012). Poly(Lactic Acid)-Based Biomaterials: Synthesis, Modification and Applications, Biomedical Science, Engineering and Technology, Dhanjoo N. Ghista (Ed.) , ISBN: 978-953-307-471-9.

荣誉、奖励及参加学术团体的情况:

• 福建省自然科学基金,面上项目,2023J01024,探索PXN相分离调控黏着斑动态组装和细胞迁移的机制,
2023-08-01-2026-08-01,6万元,在研,主持
• 国家自然科学基金委员会, 面上项目, 32071235, ASPL在应激颗粒动态平衡中的功能机制研究及其与肌萎缩侧
索硬化发生发展的潜在关系, 2021-01-01 至 2024-12-31, 57万元, 在研, 主持
• 广东省区域联合基金青年基金项目, 2020A1515111186, 自噬诱导激酶ULK1/2磷酸化Paxillin调节细胞迁移和
肿瘤浸润的机制研究, 2020-10 至 2023-9, 10万元, 在研, 主持